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Welcome to PascalX's documentation!
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PascalX is a python3 library (`source <https://github.com/BergmannLab/PascalX>`_) for high precision gene and pathway scoring for GWAS summary statistics. Aggregation of SNP p-values to gene and pathway scores follows the `Pascal <https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004714>`_ methodology, which is based on :math:`\chi^2` statistics. The cummulative distribution function of the weighted :math:`\chi^2` distribution can be calculated approximately or exactly via a multi-precision C++ implementation of Ruben's and Davies algorithm. This allows to apply the Pascal methodology to modern UK BioBank scale GWAS. In addition, PascalX offers a novel coherence test between two different GWAS on the level of genes, based on the product-normal distribution, as described `here <https://doi.org/10.1101/2021.05.16.21257289>`_.
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PascalX is a python3 library (`source <https://github.com/BergmannLab/PascalX>`_) for high precision gene and pathway scoring for GWAS summary statistics. Aggregation of SNP p-values to gene and pathway scores follows the `Pascal <https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004714>`_ methodology, which is based on :math:`\chi^2` statistics. The cumulative distribution function of the weighted :math:`\chi^2` distribution can be calculated approximately or exactly via a multi-precision C++ implementation of Ruben's and Davies algorithm. This allows to apply the Pascal methodology to modern UK BioBank scale GWAS. In addition, PascalX offers a novel coherence test between two different GWAS on the level of genes, based on the product-normal distribution, as described `here <https://doi.org/10.1101/2021.05.16.21257289>`_.
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**Highlights:**
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