-We use our OpenSPIM to study how early mammalian embryo models (using so-called mouse gastruloids) grow and develop, and how the first organs form. Especially, we are interested in how cells self-organize and orchestrate their motion to form tissue. To explain the underpinning dynamics, we couple our experiments with 3D simulations. To fully utilize light-sheet imaging, we also study collective cell migration and how nerve cells make new connections in live zebrafish, and we study the cells' own recycling system (autophagy) in Drosophila larvae.
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