diff --git a/dash/_utils.py b/dash/_utils.py
index 1c147065c4..e496357cae 100644
--- a/dash/_utils.py
+++ b/dash/_utils.py
@@ -9,6 +9,7 @@
 import io
 import json
 from functools import wraps
+import pandas as pd
 from . import exceptions
 
 logger = logging.getLogger()
@@ -18,7 +19,7 @@ def to_json(value):
     # pylint: disable=import-outside-toplevel
     from plotly.io.json import to_json_plotly
 
-    return to_json_plotly(value)
+    return to_json_plotly(serializer.serialize_tree(value))
 
 
 def interpolate_str(template, **data):
@@ -247,3 +248,50 @@ def _wrapper(*args, **kwargs):
         return _wrapper
 
     return wrapper
+
+
+class serializer:
+    @classmethod
+    def serialize(cls, prop):
+        if isinstance(prop, pd.DataFrame):
+            return {"__type": "DataFrame", "__value": prop.to_dict("records")}
+
+        return prop
+
+    @classmethod
+    def serialize_tree(cls, obj):
+        if isinstance(obj, pd.DataFrame):
+            return cls.serialize(obj)
+
+        # Plotly
+        try:
+            obj = obj.to_plotly_json()
+        except AttributeError:
+            pass
+
+        if isinstance(obj, (list, tuple)):
+            if obj:
+                # Must process list recursively even though it may be slow
+                return [cls.serialize_tree(v) for v in obj]
+
+        # Recurse into lists and dictionaries
+        if isinstance(obj, dict):
+            return {k: cls.serialize_tree(v) for k, v in obj.items()}
+
+        return obj
+
+    @classmethod
+    def unserialize(cls, prop):
+        if not (isinstance(prop, dict) and "__type" in prop):
+            return prop
+        if prop["__type"] == "DataFrame":
+            return pd.DataFrame(prop["__value"])
+
+        return prop["__value"]
+
+    @classmethod
+    def unserialize_input(cls, cb_input):
+        if "value" in cb_input:
+            return {**cb_input, "value": cls.unserialize(cb_input["value"])}
+
+        return cb_input
diff --git a/dash/dash-renderer/src/actions/callbacks.ts b/dash/dash-renderer/src/actions/callbacks.ts
index 2769d4c5eb..0997400c60 100644
--- a/dash/dash-renderer/src/actions/callbacks.ts
+++ b/dash/dash-renderer/src/actions/callbacks.ts
@@ -145,11 +145,25 @@ function fillVals(
     const inputVals = getter(paths).map((inputList: any, i: number) => {
         const [inputs, inputError] = unwrapIfNotMulti(
             paths,
-            inputList.map(({id, property, path: path_}: any) => ({
-                id,
-                property,
-                value: (path(path_, layout) as any).props[property]
-            })),
+            inputList.map(({id, property, path: path_}: any) => {
+                const type = (path(path_, layout) as any).propertyTypes?.[
+                    property
+                ];
+                let value = (path(path_, layout) as any).props[property];
+
+                if (type) {
+                    value = {
+                        __type: type,
+                        __value: value
+                    };
+                }
+
+                return {
+                    id,
+                    property,
+                    value
+                };
+            }),
             specs[i],
             cb.anyVals,
             depType
diff --git a/dash/dash-renderer/src/reducers/layout.js b/dash/dash-renderer/src/reducers/layout.js
index 6c082f313c..c5056a35de 100644
--- a/dash/dash-renderer/src/reducers/layout.js
+++ b/dash/dash-renderer/src/reducers/layout.js
@@ -1,10 +1,44 @@
-import {append, assocPath, includes, lensPath, mergeRight, view} from 'ramda';
+import {
+    append,
+    assocPath,
+    includes,
+    lensPath,
+    mergeRight,
+    view,
+    type
+} from 'ramda';
 
 import {getAction} from '../actions/constants';
 
+const processProperties = node => {
+    const updatedNode = {...node, propertyTypes: {...node.propertyTypes}};
+    const {
+        props,
+        props: {children}
+    } = node;
+
+    if (type(children) === 'Array') {
+        updatedNode.props.children = children.map(child =>
+            processProperties(child)
+        );
+    } else if (type(children) === 'Object' && !children.__type) {
+        updatedNode.props.children = processProperties(children);
+    }
+
+    Object.entries(props).forEach(([key, value]) => {
+        updatedNode.props[key] = value?.__value || value;
+        updatedNode.propertyTypes[key] =
+            value?.__type || updatedNode.propertyTypes[key] || null;
+    });
+
+    return updatedNode;
+};
+
 const layout = (state = {}, action) => {
     if (action.type === getAction('SET_LAYOUT')) {
-        return action.payload;
+        const updatedState = processProperties(action.payload);
+
+        return updatedState;
     } else if (
         includes(action.type, [
             'UNDO_PROP_CHANGE',
@@ -13,9 +47,16 @@ const layout = (state = {}, action) => {
         ])
     ) {
         const propPath = append('props', action.payload.itempath);
+
         const existingProps = view(lensPath(propPath), state);
         const mergedProps = mergeRight(existingProps, action.payload.props);
-        return assocPath(propPath, mergedProps, state);
+
+        let updatedState = assocPath(propPath, mergedProps, state);
+        if (action.payload.source === 'response') {
+            updatedState = processProperties(updatedState);
+        }
+
+        return updatedState;
     }
 
     return state;
diff --git a/dash/dash.py b/dash/dash.py
index b567e5b9d9..196a63e3ba 100644
--- a/dash/dash.py
+++ b/dash/dash.py
@@ -51,6 +51,7 @@
     split_callback_id,
     strip_relative_path,
     to_json,
+    serializer,
 )
 from . import _callback
 from . import _dash_renderer
@@ -1266,9 +1267,12 @@ def callback(_triggers, user_store_data, user_callback_args):
 
     def dispatch(self):
         body = flask.request.get_json()
+
         flask.g.inputs_list = inputs = body.get(  # pylint: disable=assigning-non-slot
             "inputs", []
         )
+        inputs = [serializer.unserialize_input(v) for v in inputs]
+
         flask.g.states_list = state = body.get(  # pylint: disable=assigning-non-slot
             "state", []
         )