diff --git a/Misc/NEWS.d/next/Build/2026-07-01-17-53-00.gh-issue-152769.Kp7mQ2.rst b/Misc/NEWS.d/next/Build/2026-07-01-17-53-00.gh-issue-152769.Kp7mQ2.rst
new file mode 100644
index 000000000000000..04a6ef4f5e0a7f8
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2026-07-01-17-53-00.gh-issue-152769.Kp7mQ2.rst
@@ -0,0 +1,4 @@
+Enable the :ref:`perf profiler <perf_profiling>` trampoline on Alpine Linux with the
+musl C library on ``x86_64`` and ``aarch64``. The
+trampoline is architecture-specific and does not depend on the C library, so
+the same assembly trampoline used for glibc is reused for musl.
diff --git a/configure b/configure
index d0738c1909be7b3..c5e25eef9d98566 100755
--- a/configure
+++ b/configure
@@ -14442,9 +14442,15 @@ case $PLATFORM_TRIPLET in #(
   x86_64-linux-gnu) :
     perf_trampoline=yes
                         PERF_TRAMPOLINE_OBJ=Python/asm_trampoline_x86_64.o ;; #(
+  x86_64-linux-musl) :
+    perf_trampoline=yes
+                        PERF_TRAMPOLINE_OBJ=Python/asm_trampoline_x86_64.o ;; #(
   aarch64-linux-gnu) :
     perf_trampoline=yes
                          PERF_TRAMPOLINE_OBJ=Python/asm_trampoline_aarch64.o ;; #(
+  aarch64-linux-musl) :
+    perf_trampoline=yes
+                         PERF_TRAMPOLINE_OBJ=Python/asm_trampoline_aarch64.o ;; #(
   darwin) :
     case $MACOSX_DEPLOYMENT_TARGET in #(
   10.[0-9]|10.1[0-1]) :
diff --git a/configure.ac b/configure.ac
index 622d6f6593a1a9c..2b5c732a9b87469 100644
--- a/configure.ac
+++ b/configure.ac
@@ -3878,8 +3878,12 @@ PERF_TRAMPOLINE_OBJ=""
 AS_CASE([$PLATFORM_TRIPLET],
   [x86_64-linux-gnu], [perf_trampoline=yes
                         PERF_TRAMPOLINE_OBJ=Python/asm_trampoline_x86_64.o],
+  [x86_64-linux-musl], [perf_trampoline=yes
+                        PERF_TRAMPOLINE_OBJ=Python/asm_trampoline_x86_64.o],
   [aarch64-linux-gnu], [perf_trampoline=yes
                          PERF_TRAMPOLINE_OBJ=Python/asm_trampoline_aarch64.o],
+  [aarch64-linux-musl], [perf_trampoline=yes
+                         PERF_TRAMPOLINE_OBJ=Python/asm_trampoline_aarch64.o],
   [darwin], [AS_CASE([$MACOSX_DEPLOYMENT_TARGET],
                 [[10.[0-9]|10.1[0-1]]], [perf_trampoline=no],
                 [perf_trampoline=yes