+ "The [ingest](https://scanpy.readthedocs.io/en/latest/api/scanpy.tl.ingest.html) function assumes an annotated reference dataset that captures the biological variability of interest. The rational is to fit a model on the reference data and use it to project new data. For the time being, this model is a PCA combined with a neighbor lookup search tree, for which we use UMAP's [[McInnes18]](https://arxiv.org/abs/1802.03426) implementation. Similar PCA-based integrations have been used before, for instance, in [Weinreb18](https://doi.org/10.1101/467886).\n",
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