MIHA SAAS SDF Merger

Tool for Merging Chemical Structure Data Files

Desktop and web applications for merging SDF files used in computational chemistry and drug discovery research.

Features

Desktop Application (Python/Tkinter)

🖥️ Intuitive GUI - User-friendly interface

📊 Batch Processing - Merge several numbers of SDF files simultaneously

🚀 Real-time Progress - Visual progress bar and detailed logging

🎯 Works on Windows

Web Application (HTML/JavaScript)

🌐 Browser-Based - No installation required

📁 Drag & Drop - Simple file selection interface

📱 Responsive Design - Works on desktop and mobile devices

Core Capabilities

✅ Merge Multiple SDF files into a single file

✅ Handle ZIP archives containing SDF files

✅ Preserve Molecular Properties from original files

For Desktop Application

For Desktop (Windows Executable)

Download the latest .exe from https://sourceforge.net/projects/sdf-merger/

Double-click to run (no installation needed)

For Web Version

Visit:

🖥️ Desktop Application Usage

Step 1: Download the Application from SourceForge

Official Download Site: https://sourceforge.net/projects/sdf-merger/

Step 2: Select Input Folder Path: All .sdf files will be automatically detected

Step 3: Choose Output Location path

Step 4: Start Merge Process

🌐 Web Application Usage

Use direct from webpage: https://ismielabir.github.io/SDF-File-Merge/

Drag & Drop: Drop SDF/ZIP files directly

Real-time Processing: Visual progress indicator

No Uploads: All processing happens locally in your browser

Instant Download: Get merged SDF file immediately

📁 File Formats Supported

Input

.sdf: Structure-Data File (standard format)

.zip: Archives containing SDF files (automatically extracted)

Output

.sdf: Single merged Structure-Data File preserving all molecular properties

🤝 Contributing: welcome contributions!

📄 License: This project is licensed under the MIT License - see the LICENSE file for details.

📝 Citation

Publication / Preprint

The SDF Merger software is described in the following preprint:

Md. Ismiel Hossen Abir. (2026). SDF Merger: A Desktop and Web Tool for Merging Chemical Structure Data Files. Zenodo. DOI: 10.5281/zenodo.18337026

Tool

The archived software release is available on Zenodo

Md. Ismiel Hossen, A. (2026). SDF Merger: A Desktop and Web Tool for Merging Chemical Structure Data Files (v1.1). Zenodo. https://doi.org/10.5281/zenodo.18291398

🙏 Acknowledgments

RDKit Community for the excellent cheminformatics toolkit

Python Software Foundation for the programming language and libraries

Thank you.