DesignForge v1.0.0: Open hotspot-guided de novo protein binder analysis and visualization

DesignForge v1.0.0

Release Highlights

• Hotspot-guided analysis of protein–protein interfaces
• Physics-based interaction profiling (OpenMM) and contact mapping workflows
• Structural benchmarking including RMSD-to-native comparisons
• Automated generation of publication-quality figures
• Compatible with BindCraft, RFdiffusion, RFDesign, and AlphaFold pipelines
• Modular, reproducible workflows with Conda environment support

Summary

DesignForge provides a unified framework for evaluating and visualizing de novo protein binder design outputs, enabling reproducible downstream analysis and streamlined figure generation across diverse protein design workflows.