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Mahanbalooei/README.md

Hi, I'm Mahan Balooei 👋🧬

🎓 Master's student in Bioinformatics at Alma Mater Studiorum – Università di Bologna
🔬 Passionate about computational biology, machine learning, and genomics
📍 Modena, Italy


🧠 About Me

I work at the intersection of biology and data science — building machine learning pipelines, analyzing genomic data, and applying statistical methods to biological problems. My projects span from classical ML to structural bioinformatics and epigenomics.


🛠️ Tech Stack

Languages

Python R Bash

ML & Data Science

scikit-learn NumPy Pandas Matplotlib

Bioinformatics

HMMER Bioconductor minfi

Tools

Git Jupyter Conda Linux


📌 Featured Projects

Profile Hidden Markov Models comparing sequence-based vs. structure-based approaches for Kunitz domain detection. Structure-based HMM achieved peak MCC of 0.997.
Python HMMER Bioinformatics Structural Biology


Differential DNA methylation analysis of CpG sites between healthy and diseased individuals using Illumina HumanMethylation450k array data.
R Bioconductor minfi Epigenomics


ML regression pipeline comparing Linear Regression, k-NN, and Random Forest with scikit-learn pipelines and GridSearchCV. Built for an Applied Machine Learning course.
Python scikit-learn Machine Learning


📊 GitHub Stats

Mahan's GitHub stats Top Languages


📫 Contact

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  1. epigenetic-methylation-450k epigenetic-methylation-450k Public

    Differential DNA methylation analysis of CpG sites between healthy and diseased individuals using Illumina HumanMethylation450k array data, R, and Bioconductor.

    R

  2. HMM_KunitzDomain HMM_KunitzDomain Public

    Building structure-informed Profile HMMs for Kunitz/BPTI-type protease inhibitor domain detection, comparing sequence-based vs. structure-based approaches with 2-fold cross-validation.

    Jupyter Notebook

  3. LB2_project_Group_7 LB2_project_Group_7 Public

    A machine learning pipeline for eukaryotic signal peptide prediction — from UniProtKB data collection to a CNN-LSTM classifier on ESM-2 embeddings. Implements and benchmarks three methods: a von He…

    Jupyter Notebook 1