Safety of Ultrasound Contrast Agents – Meta-analysis (Frequentist)

This repository accompanies the manuscript:

Type, Severity, Frequency and Management of Adverse Reactions Associated with Ultrasound Contrast Agents: A Systematic Review and Meta-Analysis

and provides the full, reproducible statistical analysis underlying the results reported in the article.

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📦 Repository contents

The repository is intentionally minimal and self-contained.

├── data-raw/                         # Publicly available extracted data
├── Meta_mdc_04092025_frequentist.Rmd  # Main analysis (R Markdown)
├── Meta_mdc_04092025_frequentist.html # Rendered HTML report
├── renv/                             # renv infrastructure
├── renv.lock                         # Exact package versions
├── uscas-adr-ma.Rproj                # RStudio project
└── .Rprofile                         # renv activation

• data-raw/ contains only publicly available data extracted from the literature.
• .Rmd is the authoritative source for all analyses, figures, and tables.
• .html is the rendered output provided for immediate inspection, without requiring R.
• renv.lock guarantees computational reproducibility.

No private data, credentials, API keys, or sensitive information are included.

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🔁 Reproducibility

The analysis is fully reproducible.

Requirements

• R (≥ 4.4.0 recommended)
• RStudio (optional, but recommended)

Steps

# Restore the exact package environment
renv::restore()

# Render the analysis
rmarkdown::render("Meta_mdc_04092025_frequentist.Rmd")

The rendered HTML will reproduce the results reported in the manuscript.

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🔒 Data and privacy

• All data included in this repository are publicly available.
• No patient-level, identifiable, or restricted data are present.
• No secrets or environment variables are required.

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📜 License

This repository is provided for scientific transparency and reproducibility.

Unless otherwise stated in the manuscript or journal policy:

• Code is released for academic and research use.
• Data reuse must follow the original sources’ licensing terms.

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✉️ Contact

For questions regarding the analysis or reproducibility, please refer to the corresponding author listed in the manuscript.