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qFoldIT — Science, Compiled into Foldnite Missions

LEGO brick road to open science on the cover of Trends in Biotechnology, September 2022. Predicting chemical reactivity in a digital lab. An adaptive graph learning method for automated molecular interactions and properties predictions, June 2022.

ANTHROPIC

qFoldIT Pipeline UEFN MCP

qFoldIT — scientific computing, human-in-the-loop discovery and interactive runtimes

GAMEPLAY - LEGO FORTNITE SCIENCE/TSMC GAMEPLAY - LEGO FORTNITE SCIENCE GAMEPLAY - LEGO FORTNITE SCIENCE

qFoldIT — Science, Compiled into Missions

Contract-first scientific computing and human-in-the-loop discovery across MCP, UAG, simulation and interactive runtimes.

GitHub Organization · Public State & Project Site · IP & Evidence Registry · Canonical Architecture


Organization Identity

Foldnite / qFoldIT is a scientific mission infrastructure organization turning scientific and industrial objectives into governed, executable and auditable human/AI missions.

What qFoldIT is

qFoldIT is a scientific mission platform that converts research and industrial objectives into governed, executable and auditable human/AI missions.

The platform separates scientific authority from presentation, gameplay, learning and commercial policy:

Scientific / Industrial Objective
        ↓
Mission Contract
        ↓
Capability Profile
        ↓
Mission Router
        ↓
Mission Compiler
        ↓
UAG / Scientific Object Model
        ↓
Runtime Adapter
        ↓
Human + AI Search
        ↓
Submission / Event
        ↓
CAMEO Reconciliation
        ↓
Scientific Validation
        ↓
Evidence / Contribution Record
        ↓
STATE Projection
        ↓
Enterprise Deliverable

The result is not merely a game level. It is a validated scientific workflow that can be rendered as an interactive experience when that is the best interface for the mission.

qFoldIT in Claude / MCP environments

qFoldIT is designed to operate as a scientific capability fabric for MCP-compatible agents, including Claude-based research workflows.

The correct boundary is:

Claude / Scientific Agent
        ↓
MCP Scientific Tools & Services
        ↓
qFoldIT Mission Contract
        ↓
UAG / Scientific Object Model
        ↓
Mission Compiler / Runtime Adapter
        ↓
Execution
        ↓
Scientific Validator

Claude is an orchestration and reasoning interface. Scientific truth remains external to the conversational layer and is established by the configured scientific validators and customer-authorized reference boundaries.

Core architecture

Layer Function Representative qFoldIT surfaces
Governance Rights, provenance, contracts, evidence .github, .github-private, IP-valuation-registry
Enterprise Control Plane Customer objectives and mission lifecycle CORPORATE_APP
Compilation Routing and deterministic mission compilation CORPORATE_APP, conformance fixtures
Scientific Object Model Canonical scientific/world representation Scientific-Object-Schema, UAG
Scientific MCP Mesh Machine-readable tools and agents Protein-MCP, Protein-Design-MCP, Atomic-MCP, scientific skills
Validation Fabric Authoritative scientific scoring OPENSTRUCTURE, domain validators, quantum services
Reconciliation Runtime submission → scientific evidence CAMEO-REALTIME-VALIDATION, INDUSTRIAL-CAMEO
Runtime Mesh Engine/browser/desktop execution UEFN, Unity, UNIGINE, Web, Standalone
Learning Strategy/coaching/compute optimization learning-policy and mission optimization
Attention / Presentation Participation and distribution narrative and interactive game layers
Commercial Policy Eligibility, rights, rewards and customer policy enterprise policy layer
STATE Safe public/organizational projection qfoldit.github.io

Runtime adapters

One scientific representation can be delivered through multiple interaction surfaces:

                    Canonical UAG / Scientific State
                                │
          ┌─────────────────────┼─────────────────────┐
          │                     │                     │
        UEFN                  Unity                 UNIGINE
          │                     │                     │
   UEFN-TOOLBELT         UNITY-TOOLBELT       UNIGINE-TOOLBELT
          │                     │                     │
          └─────────────────────┼─────────────────────┘
                                │
                          WEB-TOOLBELT
                                │
                         STANDALONE APP

Runtime adapters are execution surfaces, not scientific authorities.

Scientific validation

qFoldIT's current OpenStructure integration establishes a server-side scientific validation boundary with protected references and native structural scoring.

CORPORATE_APP
      ↓ authenticated server-side request
OPENSTRUCTURE qFoldIT service
      ↓
OpenStructure / `ost`
      ↓
LDDT / local-LDDT / QS-score
      ↓
ValidationResult
      ↓
validation.completed + audit evidence

A failed validator does not become a score by fallback logic. This fail-closed rule is fundamental to the qFoldIT evidence model.

CAMEO and three clocks

qFoldIT distinguishes:

  1. Authoring clock — target creation and mission compilation.
  2. Runtime clock — interaction and event capture.
  3. Reconciliation clock — external scientific validation and evidence publication.

For UEFN this distinction is essential: live Verse execution is not treated as a direct arbitrary-network scientific client. The intended model is runtime interaction → session publication → external reconciliation → scientific validation.

Human + AI discovery

qFoldIT treats players and agents as search participants rather than as sources of scientific truth.

Mission State
+ Player / Agent State
+ Historical Outcomes
+ Compute State
        ↓
Learning Policy
        ↓
Decision / Coaching
        ↓
Runtime Outcome
        ↓
Validation
        ↓
Evidence
        ↓
Policy Update

The target metric is validated scientific contribution density, not raw playtime.

Scientific mission domains

qFoldIT's mission architecture is designed for:

  • protein and peptide design;
  • structural biology and molecular modeling;
  • drug discovery and ADMET;
  • synthetic biology and L-systems;
  • materials and crystal search;
  • batteries and energy storage;
  • semiconductors and AI hardware;
  • quantum computing and hybrid optimization;
  • aerospace and space science;
  • energy, hydrogen and CCUS;
  • mining and resource processing;
  • industrial engineering and process optimization;
  • scientific software and cloud AI.

Evidence discipline

qFoldIT distinguishes:

  • E1 — verified implementation evidence;
  • E2 — strong architecture/product evidence;
  • E3 — design, roadmap or option evidence;
  • EX — third-party/upstream evidence.

Repository size, external ecosystem reach, prospect lists, TAM, gameplay hypotheses and third-party scientific achievements are not automatically qFoldIT-owned value or revenue evidence.

Visual and interaction heritage

qFoldIT UEFN Toolbelt

NARRATIVE CONTROL CENTER

qFoldIT — scientific computing, human-in-the-loop discovery and interactive runtimes

Explore

Built on the open Model Context Protocol (MCP) standard.

Scientific authority remains with validated scientific services and authorized reference boundaries.

Global Headquarters: Elkridge, Maryland, USA
CEO: qFoldIT CEO
Email: qFoldIT@gmail.com

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  1. QuPepFold QuPepFold Public

    Python 1

Repositories

Showing 10 of 32 repositories
  • qfoldit.github.io Public

    The Future of Molecular Design And Synthetic Biology Workflows. Using Distributed Architecture And 3D Engines. A multiplayer scientific research simulator that combines game mechanics, real-world scientific calculations (bioinformatics, quantum chemistry), and an economic model for crowdsourcing R&D.

    qfoldit/qfoldit.github.io's past year of commit activity
    HTML 4 AGPL-3.0 0 0 0 Updated Nov 6, 2026
  • GLAM Public Forked from yvquanli/GLAM

    Code for "An adaptive graph learning method for automated molecular interactions and properties predictions".

    qfoldit/GLAM's past year of commit activity
    Python 1 MIT 12 0 0 Updated Nov 2, 2026
  • .github Public

    The Future of Molecular Design And Synthetic Biology Workflows. Using Distributed Architecture And 3D Engines. A multiplayer scientific research simulator that combines game mechanics, real-world scientific calculations (bioinformatics, quantum chemistry), and an economic model for crowdsourcing R&D.

    qfoldit/.github's past year of commit activity
    Python 0 0 0 0 Updated Oct 24, 2026
  • qfoldit/CAMEO-REALTIME-VALIDATION's past year of commit activity
    Python 1 AGPL-3.0 0 0 0 Updated Oct 17, 2026
  • WEB-TOOLBELT Public
    qfoldit/WEB-TOOLBELT's past year of commit activity
    JavaScript 3 0 0 0 Updated Oct 17, 2026
  • UNIGINE-TOOLBELT Public

    80 composite editor-automation tools for UNIGINE 2, exposed to AI agents via a companion MCP bridge that sits alongside UNIGINE's own official MCPBridge Plugin.

    qfoldit/UNIGINE-TOOLBELT's past year of commit activity
    C# 6 0 0 0 Updated Oct 17, 2026
  • UNITY-TOOLBELT Public

    102 composite editor-automation tools for Unity, exposed to AI agents through Unity's own official MCP bridge.

    qfoldit/UNITY-TOOLBELT's past year of commit activity
    C# 4 0 0 0 Updated Oct 17, 2026
  • UEFN-TOOLBELT Public

    The ultimate, ever-expanding Swiss Army Knife for the UEFN Python API (358+ tools registered across 55+ categories). Automate world-building, manage assets, generate boilerplate Verse code, and control the editor with AI via a fully-offline PySide6 dashboard.

    qfoldit/UEFN-TOOLBELT's past year of commit activity
    Python 6 0 0 0 Updated Oct 12, 2026
  • ersilia-qfoldit-bridge Public

    ersilia-qfoldit-bridge

    qfoldit/ersilia-qfoldit-bridge's past year of commit activity
    0 AGPL-3.0 0 0 0 Updated Sep 3, 2026
  • QuPepFold Public
    qfoldit/QuPepFold's past year of commit activity
    Python 1 MIT 0 0 0 Updated Sep 3, 2026