The ADReCS severity-grading model consists of three steps:

• Step1: Input ADR reports data.
• Step2: Calculate ADR Severity_score.
• Step3: ADR Severity Grading.

Input files: report_data.txt and drug_adr_ROR.txt.

1. The report_data.txt needs four columns:
   • substance_name: drug name.
   • pt_term: ADR term.
   • report_source: adverse event reports ID (custom ID used for unique identification of reports).
   • reaction_outcome: outcome of the reaction in FAERS.
2. The drug_adr_ROR.txt needs three columns:
   • substance_name: drug name.
   • pt_term: ADR term.
   • drug_adr_pair_ROR: The reporting odds ratio (ROR) for ADR induced by Drug was calculated based on the two-by-two contingency table.